患有神经性和非神经性下尿路功能障碍的儿童的尿路生物标志物:系统性审查和元分析
Cagri Akin Sekerci1, Selcuk Yucel1, Tufan Tarcan1,2
1Department of Urology, Division of Pediatric Urology, School of Medicine, Marmara University, Istanbul, Turkey.
Neurourology and urodynamics
|January 19, 2024
概括
像神经生长因子 (NGF) 这样的尿路生物标志物在儿童下尿路功能障碍 (LUTD) 的诊断方面表现有前途. 需要进一步的研究来确认它们在非侵入性诊断中的临床实用性.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 生物标志物研究 生物标志物研究
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 下泌尿道功能障碍 (LUTD) 影响儿童,包括神经性和非神经性疾病.
- 准确的诊断和监测LUTD对于儿童群体的有效管理至关重要.
- 对于儿科患者来说,非侵入性诊断工具是非常理想的.
研究的目的:
- 系统地审查和评估在被诊断为神经性和非神经性下尿路功能障碍 (LUTD) 的儿童中研究的尿路生物标志物.
- 确定常被研究的生物标志物,并评估它们在反映临床和泌尿动力学发现方面的潜力.
主要方法:
- 按照PRISMA指导方针进行了系统审查,对PubMed进行了选,没有日期限制.
- 包括原始文章,提取研究设计,参与者特征,生物标志物,测量技术和尿动力学发现的数据.
- 质量评估使用了荷兰Cochrane检查清单 (DCC) 和EBRO平台;元分析使用综合元分析软件进行.
主要成果:
- 包括16项研究,其中11项是非神经性LUTD,5项是神经性LUTD.
- 神经生长因子 (NGF) 是最常被研究的生物标志物 (12项研究),其次是来自大脑的神经营养因子 (BDNF) (5项研究).
- 分析显示,与健康对照人群相比,非神经性LUTD儿童的尿NGF水平显著更高 (p<0.0001).
结论:
- 尿路生物标志物显示出作为诊断儿童LUTD的非侵入性工具的潜力.
- 用更大的队列进行进一步的前性研究至关重要,以验证这些生物标志物的作用,反映尿动力学和临床结果.
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