轻度认知障碍/痴呆症患者的死亡率和活力之间的关系:一项为期8年的回顾性研究
Yujiro Kuroda1, Taiki Sugimoto1, Kenichi Satoh2
1Department of Prevention and Care Science, Center for Development of Advanced Medicine for Dementia, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Geriatrics & gerontology international
|January 19, 2024
概括
活力显著影响认知障碍的老年人生存率. 较低的活力得分,表明日常功能受损,与较高的死亡率有关,由日常生活活动介导.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 患有轻度认知障碍 (MCI) 或痴呆症的老年人面临复杂的健康挑战.
- 评估影响这一群体生存的因素对于临床护理和公共卫生战略至关重要.
研究的目的:
- 调查活力指数 (Vix) 测量的活力与患有MCI或痴呆症的老年人生存结果之间的关联.
- 在这种关系中探索潜在的调解因素,包括BMI,日常生活的工具活动 (IADL) 和日常生活的基本活动 (BADL).
主要方法:
- 分析了国家老年病学和老年病学中心3731名患者的数据 - 痴呆症患者生活故事队列 (2010-2018).
- 使用考克斯的比例危险模型,Vix得分与死亡时间的相关性.
- 调解分析以评估BMI,IADL和BADL的作用.
主要成果:
- 包括2740名患者,死亡率为15.7%,平均随访时间为1315天.
- 较低的Vix分数 (中度到严重受损) 与明显更高的死亡率有关.
- BMI,IADL和BADL被确定为生命力-死亡率关联中的显著调解者.
结论:
- 活力是认知障碍的老年人生存的重要预测因素.
- 活力和死亡之间的联系在很大程度上是由日常生活的工具和基本活动调解的.
- 这些发现强调了评估和潜在地改善活力的临床重要性,以提高这一人口群体的生存率.
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