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年龄对自闭症遗传性和自闭症特征的病因稳定性的影响
Miriam I Martini1, Agnieszka Butwicka1,2,3,4, Ebba Du Rietz1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Journal of child psychology and psychiatry, and allied disciplines
|January 19, 2024
概括
遗传因素显著影响自闭症和自闭症的特征在整个生命. 从童年到成年,遗传性仍然很高,随着时间的推移,稳定和新的遗传影响都会出现.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学是一种遗传学.
- 发展心理学 发展心理学
背景情况:
- 自闭症和自闭症特征出现在童年,并持续到成年.
- 了解整个生命周期对自闭症的遗传和环境影响是有限的.
- 该研究调查了自闭症病因和自闭症特征的年龄相关变化.
研究的目的:
- 确定年龄对临床诊断自闭症遗传性的影响.
- 评估自闭症特征从童年到成年期的病因稳定性.
- 在不同年龄组中区分遗传,共享和非共享的环境影响对自闭症的影响.
主要方法:
- 利用瑞典双胞胎登记 (23,849对双胞胎) 进行自闭症诊断遗传性.
- 对自闭症特征的纵向数据 (1348对双胞胎) 采用多变量双胞胎分析.
- 在多个时间点使用儿童行为检查表评估了自闭症特征的表型和病因稳定性.
主要成果:
- 自闭症的遗传性很高,在童年 (96%) 和成年 (87%) 中相当.
- 自闭症特征从童年到成年期表现出中等稳定性 (r=0.35-0.61).
- 自闭症特征的遗传率在52-71%之间,观察到稳定和新的遗传影响,以及独特的环境因素.
结论:
- 遗传因素在自闭症和成年期自闭症特征中起着至关重要的作用.
- 这些发现支持了专注于成人自闭症的基因研究的必要性.
- 自闭症特征的病因因素表现出稳定性和从童年到成年时代的变化.
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