婴儿肺功能和早期皮肤屏障损害在3岁时喘的发展
Martin Färdig1,2, Angela Hoyer1,2, Catarina Almqvist2,3
1Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Allergy
|January 19, 2024
概括
低肺功能或皮肤屏障功能受损的婴儿在三岁时面临患喘的风险更高. 湿疹和费拉格林 (FLG) 突变仅在患有亚托皮炎或过敏敏感症的儿童中与喘有关.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 皮肤病学 皮肤病学
背景情况:
- 儿童早期喘的发展是多因素的.
- 诸如肺功能,皮肤屏障完整性,湿疹和遗传倾向 (filaggrin突变) 等因素都与此有关,但尚未完全理解.
- 研究这些早期生命标志物可能会揭示有关喘发病的关键见解.
研究的目的:
- 检查生命早期指标 (肺功能,皮肤屏障功能,湿疹,FLG突变) 与三岁时喘发展之间的关联.
- 探索这些关联中的潜在的性别特异差异.
主要方法:
- 利用了PreventADALL随机对照干预研究中的数据.
- 在3岁时对1337名儿童进行了喘评估,评估了3个月后的肺功能 (潮排气流/排气时间达到峰值的时间),跨皮肤水分流失 (TEWL),湿疹和FLG突变.
- 使用后勤回归模型分析关联,报告调整的赔率比率 (aOR) 和95%置信区间 (CI).
主要成果:
- 下肺功能 (tPTEF/tE <0.25) 和皮肤屏障受损 (TEWL >9.50 g/m2/h) 与喘风险增加显著相关 (aOR分别为5.4和1.6).
- 湿疹和FLG突变仅在患有亚托皮炎或过敏敏感症的儿童中与喘有关.
- 性别分层分析显示,患有下肺功能 (aOR 7.7) 的男孩和患有FLG突变 (aOR 3.5) 的女孩患喘风险增加.
结论:
- 婴儿期下肺功能和皮肤屏障功能受损是三岁前发展喘的潜在危险因素.
- 这些发现强调了早期呼吸系统和皮肤健康评估在预测儿童喘方面的重要性.
- 性别特定的关联表明男孩和女孩喘的发展途径不同.
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