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Updated: Jul 5, 2025

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通过理性调进行无痕和蛋白质修饰

Chuan Wan1,2, Yichi Zhang1, Jinpeng Wang1

  • 1State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of the American Chemical Society
|January 19, 2024
PubMed
概括

我们开发了一种无痕,可选择性和蛋白质修饰的新平台. 这种方法允许可调节的结合和分裂,使抗体修饰和蛋白质组标记等应用成为可能.

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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