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一个最小的PBPK模型,以加速对结核病药物的临床前开发

Federico Reali1, Anna Fochesato1,2, Chanchala Kaddi3

  • 1Fondazione The Microsoft Research-University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.

Frontiers in pharmacology
|January 19, 2024
PubMed
概括

这项研究引入了一种简化生理学基础的药理动力学 (PBPK) 模型,用于预测小鼠肺中的抗结核 (TB) 药物分布. 新的框架加速了分析,有助于开发更有效的结核病治疗方法.

关键词:
抗结核剂是一种抗结核剂.mPBPKK 的意思是最小的PBPK模型模型信息化药物开发模型建模 建模模型 建模模型模拟模拟是指一个模拟模拟.结核病是一种肺结核病.

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