维生素D与青少年甲状腺功能低下症之间的关系 - 一项横截面研究
Ainur Donayeva1, Dinara Kulzhanova1, Ainur Amanzholkyzy1
1Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Przeglad menopauzalny = Menopause review
|January 19, 2024
概括
患有维生素D缺乏症的青少年患甲状腺功能低下的几率增加. 较低的25-OH-D水平与较高的TSH和较低的自由T4相关,这表明在青少年中维生素D状态和甲状腺功能之间存在显著的联系.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是一个日益严重的全球健康问题.
- 甲状腺功能障碍,包括甲状腺功能低下症,影响了青少年人口的很大一部分.
研究的目的:
- 调查25~OH) D水平与青少年甲状腺功能低下之间的关联.
- 为了确定维生素D缺乏是否会增加患甲状腺功能低下症的风险.
主要方法:
- 一项涉及西哈萨克斯坦180名青少年2年的研究.
- 测量甲状腺兴奋激素 (TSH),自由甲状腺素 (T4) 和25(OH) D水平.
- 相关性分析 (皮尔森) 和MedCalc评估甲状腺功能低下的几率.
主要成果:
- 与对照组相比,患有25[OH]D缺乏症的青少年在统计学上表现出较高的TSH和较低的自由T4水平.
- 在25~OH) D缺乏组中,观察到亚临床 (OR 4.89) 和临床甲状腺功能低下 (OR 4.3) 的可能性更高.
- 显著的负相关性在25OH) D和TSH之间 (r = -0.793),和25OH) D和自由T4之间的正相关性 (r = 0.55).
结论:
- 维生素D缺乏与青少年患亚临床和临床甲状腺功能低下的几率增加有显著的关联.
- 较低的25-OH-D水平与较差的甲状腺功能标志物 (较高的TSH,较低的T4) 有关.
- 这些发现强调了监测甲状腺功能障碍的青少年维生素D状况的重要性.
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