双刺激响应的聚合物纳米粒子结合soluplus和chitosan用于增强乳腺癌向
Shrouq Twal1,2, Nisrein Jaber3, Mayyas Al-Remawi1
1Faculty of Pharmacy and Medical Sciences, University of Petra Amman 1196 Jordan malremawi@uop.edu.jo (+962) 797683190.
RSC advances
|January 19, 2024
概括
智能酸盐-soluplus纳米颗粒被开发用于双刺激响应药物输送. 这些纳米颗粒有效地提供抗癌药物,显示出增强的疗效和针对癌症治疗的向药物.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 新型纳米载体的开发对于改善癌症治疗至关重要.
- 刺激响应系统提供了增强的药物向性和减少副作用.
- 奇托和Soluplus共聚物为纳米载体开发提供了有前途的生物相容材料.
研究的目的:
- 开发和表征双刺激响应纳米粒子 (CS-SP NPs) 以增强抗癌药物递送.
- 将泰莫西芬酸盐 (TC) 封装到CS-SPNP中,并评估其性能.
- 调查药物载入纳米粒子的pH和温度反应性行为和细胞毒性.
主要方法:
- 合成和表征酸盐-soluplus移植共聚合物.
- 纳莫西芬酸盐 (TC) 封装成酸盐-soluplus纳米颗粒 (CS-SP NPs).
- 物理化学表征 (粒子大小,泽塔潜力,形态,封装效率) 和体外评估 (药物释放,细胞毒性,细胞吸收).
主要成果:
- 优化的CS-SPNP表现出球形形态 (大约. 94纳米) 具有高封装效率 (约. 这是96.66%的百分比.
- 该纳米载体表现出双刺激反应行为 (pH和温度),在酸性pH和40°C时触发药物释放.
- 在40°C时观察到对MCF7细胞的增强细胞毒性 (3.5倍增加),在癌细胞系中细胞吸收成功.
结论:
- 新型酸盐-soluplus纳米颗粒 (CS-SP NPs) 代表了一种有前途的智能纳米平台,用于有效的药物输送.
- 双刺激响应性增强了向药物释放,并提高了抗癌疗效.
- 这种纳米载体系统有可能促进癌症治疗策略的发展.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
11.0K
05:55Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
Published on: September 18, 2018
8.8K
相关概念视频
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...