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胸腔液残留物作为细胞学阴性恶性胸腔输液的诊断工具:一项概念验证研究
L E Nyanti1, N-C Huan2, H Y Ramarmurty2
1Medical Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia.
African journal of thoracic and critical care medicine
|January 19, 2024
概括
胸腔液残留物在细胞学阴性病例中显示出对诊断恶性胸腔溢出有前途. 然而,在此初步研究中,它没有为结核溢出提供额外的诊断价值.
科学领域:
- 肺部病理学 肺部病理学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 腹液残留物,腹液中的宏观组织,可能提供诊断性病理学信息.
- 像胸腔活检这样的传统方法是侵入性的.
- 诊断恶性肺溢液 (MPE) 和结核性肺溢液 (TPE) 可能具有挑战性.
研究的目的:
- 在诊断TPE和MPE时,与膜活检相比,评估膜液残留物的组织病理学一致性.
- 评估细胞学阴性排泄液中多液残留物的诊断效用.
主要方法:
- 连续住院患者的前性队列研究,细胞学阴性排泄性输液.
- 患者接受了多镜检查,并进行多液过以检测残留样本.
- 胸腔液残留物的组织病理学分析和与胸腔活检结果的比较.
主要成果:
- 在7例活检确认的恶性瘤病例中,4例中检测到多液残留的恶性细胞.
- 残留物显示出类似的细胞形态,但细胞性低于活检.
- 在多液残留样本中没有发现结核组织学特征.
结论:
- 胸腔液残留物提供了作为一种非侵入性方法,用于诊断出血流中的恶性瘤的潜力.
- 该方法为MPE提供了基因病理信息,但并未为TPE提供增量诊断价值.
- 需要进一步验证和更大的研究来证实实用性,特别是用于突变分析.
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