奎瑞通过TLR4/IRAK4/NF-κB信号通路抑制树突细胞的活性和功能

Chenglin Kang1,2,3, Xiaomei Li3, Peng Liu1,2

  • 1Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai Campus, Zhuhai, People's Republic of China.

Contemporary oncology (Poznan, Poland)
|January 19, 2024
PubMed
概括

奎尔赛丁 (QUE) 通过向类似收费受体4/互乐金-1受体关联激酶4/核因子kappa-B (TLR4/IRAK4/NF-κB) 途径来抑制树突细胞 (DC) 的活性. 这表明IRAK4是调节DC功能的潜在治疗标.

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K