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Updated: Aug 16, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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以结构功能为指导的合成的设计,具有来自黄蜂毒液的抗感染活性

Andreia Boaro1,2,3,4,5, Lucía Ageitos1,2,3,6,5, Marcelo Der Torossian Torres1,2,3

  • 1Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell reports. Physical science
|January 19, 2024
PubMed
概括

科学家们从黄蜂毒中改造出抗微生物 (AMP) 来制造出更少毒性的α螺旋版本. 这些新型抗生素有效地杀死了阴性细菌,并且在没有快速耐药性发展的情况下,在临床前模型中显示出有希望的结果.

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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation11:09

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