血管功能的变化和与新诊断的乳腺癌患者接受HER2导向治疗的女性的心脏毒性相关性,包括使用或不使用Anthracycline/cyclophosphamide
Antonious Hazim1, Lara F Nhola2, Vidur Kailash2
1Department of Oncology, Mayo Clinic, Rochester, MN, USA.
European heart journal open
|January 19, 2024
概括
在乳腺癌患者中,与HER2导向疗法 (HER2-Tx) 结合的抗环素/cyclophosphamide (AC) 化疗显著损害了周围血管功能和心脏功能. 单独使用HER2-Tx并没有显示这些不良影响.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对HER2的治疗 (HER2-Tx) 对HER2阳性乳腺癌至关重要.
- 人类循环素/cyclophosphamide (AC) 化学疗法经常同时使用.
- 心脏毒性和血管功能障碍是癌症治疗的潜在副作用.
研究的目的:
- 评估HER2-Tx对外周血管活性的影响.
- 评估血管功能,心脏功能变化和化疗方案之间的相关性.
- 为了研究AC治疗和基线心血管风险的附加效应.
主要方法:
- 对47名患有HER2阳性乳腺癌的女性进行前性队列研究.
- 评估包括内周动脉度测量 (Endo-PAT),血管生物标志物 (CNP,NRG-1β) 和心声回声.
- 心脏毒性定义为>10%的LVEF下降到<53%.
主要成果:
- 在接受HER2-Tx加AC (65%) 和单独接受HER2-Tx (22%) 的患者中,反应性高血压指数 (RHI) 的恶化显著更高.
- 与非AC接受者相比,接受AC治疗的患者在3个月后显示出明显较低的3D LVEF.
- 反应性高血压指数和全球纵向应变 (GLS) 与LVEF变化相关.
结论:
- 与AC和HER2-Tx的联合治疗,但不仅仅是HER2-Tx,导致外周血管和心脏功能下降.
- 需要进一步的研究来澄清接受这些疗法的癌症患者血管和心脏变化之间的因果关系.
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