第一次出生时的年龄,更年期的年龄和卵巢囊的风险:一个两样本的门德尔随机化研究
1Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China.
Frontiers in endocrinology
|January 19, 2024
概括
这项研究发现,较早的第一个出生年龄 (AFB) 和较早的初潮年龄 (AAM) 降低了卵巢囊 (OC) 的风险,而较晚的自然更年期 (ANM) 增加了OC风险. 这些生殖因素因果关系地影响卵巢囊的发展.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇科疾病研究研究.
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,激素生殖因素与卵巢囊 (OC) 有关.
- 卵巢囊是一种常见的妇科疾病.
- 了解生殖因素和OC之间的因果关系对于预防和管理至关重要.
研究的目的:
- 使用双样本孟德尔随机化 (MR) 方法,研究关键生殖因素对卵巢囊 (OC) 风险的因果关系.
- 检查第一个出生时的年龄 (AFB),自然绝经时的年龄 (ANM) 和初潮时的年龄 (AAM) 对OC发育的影响.
- 为了澄清这些因果关系的方向和大小.
主要方法:
- 一个两样本的门德尔随机化 (MR) 研究,利用大型全基因组关联研究 (GWAS) 总结统计数据.
- 选择单核酸多态 (SNP) 作为AFB (51个SNP),ANM (35个SNP) 和AAM (6个SNP) 的仪器变量.
- 应用多种MR方法 (IVW,MR-Egger,加权中位数) 和MR-PRESSO用于稳健性和性质的评估,并对像BMI和吸烟状况这样的混因素进行调整.
主要成果:
- 第一次出生时的年龄 (AFB) 与卵巢囊 (OC) 风险有显著的负因果关联 (IVW OR:0.91).
- 初潮时的较大年龄 (AAM) 与降低OC风险相关 (IVW OR:0.91).
- 自然更年期的年龄 (ANM) 表明与OC风险存在显著的积极因果关系 (IVW OR: 1.05).
- 混调整 (BMI,酒精,吸烟,身高,体重) 强化了这些因果关系,特别强调年轻的AFB,年轻的AAM和年长的ANM作为风险因素.
结论:
- 包括AFB,ANM和AAM在内的生殖因素对卵巢囊 (OC) 发育产生了令人信服的因果关系.
- 第一次出生时的年龄较小和初潮时的年龄较小与OC的风险降低有关.
- 自然更年期的年龄较大与OC的风险增加有因果关系,即使经过对潜在的混因素进行调整.
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