癌症患者中PD-1/PD-L1抑制剂诱导的免疫相关甲状腺功能障碍相关的因素:一项观察性研究
Xiao-Chen Wei1, Yuan-Yuan Guo1, Yi Zhang1
1Department of Pharmacy, Tianjin First Central Hospital, Tianjin, P.R. China.
Journal of chemotherapy (Florence, Italy)
|January 19, 2024
概括
接受编程死亡1 (PD-1) /编程死亡联体1 (PD-L1) 抑制剂的癌症患者可能会出现免疫性甲状腺功能障碍. 与氨酸激酶抑制剂和高抗TPO水平的联合治疗是危险因素.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 与免疫相关的不良事件 (irAEs) 在接受免疫检查点抑制剂治疗的癌症患者中很常见.
- 甲状腺功能障碍是显著的irAE,影响患者的管理和结果.
研究的目的:
- 在接受PD-1/PD-L1抑制剂治疗的癌症患者中识别与免疫甲状腺功能障碍相关的因素.
- 开发甲状腺IRAEs的预测模型.
主要方法:
- 175名癌症患者接受PD-1/PD-L1抑制剂治疗的回顾性研究.
- 甲状腺irrAEs的分析,包括甲状腺功能低下症,甲状腺功能过强症和甲状腺毒性病.
- 多变量逻辑回归和名ogram建模.
主要成果:
- 27%的患者发生了甲状腺激进反应.
- 与PD-1/PD-L1抑制剂和铁激酶抑制剂 (伦瓦提尼布/雷戈拉费尼布) 的联合治疗与风险增加有关.
- 高基线抗甲状腺过氧化酶 (抗TPO) 抗体水平也是一个显著的危险因素.
结论:
- 组合疗法和基线抗TPO水平的升高是治疗PD-1/PD-L1抑制剂的患者甲状腺IRE的关键预测因素.
- 开发的诺莫格拉姆模型显示出良好的预测能力.
- 为了证实这些发现,需要在更大的队列中进一步验证.
相关概念视频
Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Autoimmune Disorders
442
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
442


