Ralstonia pickettii 血流感染与国际分布的污染盐溶液的潜在基因组联系,德国,2023年10月
Manuel Krone1,2, Vera Rauschenberger1,2, Vera Blaschke1,2
1University Hospital Würzburg, Infection Control and Antimicrobial Stewardship Unit, Würzburg, Germany.
概括
由Ralstonia pickettii引起的侵入性感染与受污染的医疗产品有关. 整个基因组测序表明了一个未知的共同来源,突出了这些细菌潜在的全球风险.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 拉尔斯托尼亚皮克蒂 (Ralstonia pickettii) 是一种格拉姆阴性细菌,可以引起严重的感染,特别是在污染液体医疗产品时.
- 在患者的血培养和干细胞产品中检测到R. pickettii促使对其来源进行调查.
研究的目的:
- 在三名患者中调查Ralstonia pickettii感染的来源.
- 为了确定患者隔离物和环境菌株之间的关系.
- 评估医疗产品中常见污染源的可能性.
主要方法:
- 全基因组测序 (WGS) 在三个患者隔离物和两个环境水隔离物上进行.
- 核心基因组多部位序列类型 (cgMLST) 用于详细的基因组比较.
- 基因组比较包括一个已知的R. pickettii集群,与受污染的盐水有关.
主要成果:
- 患者隔离物与彼此密切相关,但与环境隔离物不同.
- 患者隔离显示与与印度盐水相关的澳大利亚R. pickettii集群有着遥远的关系.
- 链接的医疗产品来自欧洲和美国,而不是印度.
结论:
- 这些发现表明,来自未知的常见R. pickettii污染源的持续风险.
- 可能在全球分布的医疗产品可能与这次疫情有关.
- 调查侵袭性R. pickettii感染WGS对于识别来源和预防疫情至关重要.
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