在杜皮卢马布或特拉洛基努马布治疗阿托皮性皮炎后注射部位反应
Fabrizio Martora1, Cataldo Patruno2, Silvia D'Ascenzo1
1Section of Dermatology - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
The Journal of dermatological treatment
|January 19, 2024
概括
注射部位反应 (ISR) 在皮下生物注射时很常见. 与杜皮卢马布相比,特拉洛金努马布的ISR频率更高,尽管反应通常是轻微的,并且没有导致治疗中止.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 注射部位反应 (ISR) 是一种局部不良事件,其特征是注射部位的胀,红血,和疼痛.
- 在下皮注射生物药物后,经常报告ISR.
研究的目的:
- 为了比较dupilumab和tralokinumab之间ISRs的频率,持续时间和强度,在阿托皮性皮肤炎患者中.
- 为了评估两个常用的生物治疗的现实世界ISR数据.
主要方法:
- 从2023年1月到2023年6月进行了一项观察性实践研究.
- 纳入了接受dupilumab或tralokinumab的中度至重度亚托邦性皮炎的成年患者.
- 一个12项调查问卷评估了ISR症状和特征.
主要成果:
- 总共有392名患者被纳入分析.
- 在这两组治疗中,ISRs是常见的,特拉洛金努马布与反应的频率比杜皮卢马布更高.
- 大多数ISR的严重程度是轻微的.
结论:
- 杜皮卢马布和特拉洛基努马布都可能在患有亚托皮炎的患者中引起ISR.
- 与dupilumab相比,特拉洛金努马布的ISR发生率更高.
- 尽管ISR的发生频率较高,但ISR通常是轻微的,并没有导致治疗停止.
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