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分子降解剂:为新药发现提供了令人兴奋的机会

Thomas Lemaitre1, Marie Cornu1, Florian Schwalen1,2

  • 1Normandie University, UNICAEN, CERMN, Caen, France.

Expert opinion on drug discovery
|January 19, 2024
PubMed
概括

分子粘合剂降解剂 (MGDs) 增强蛋白质与蛋白质的相互作用,以向以前无法处理的蛋白质. 本综述探讨了MGD设计策略及其在治疗具有挑战性的疾病方面的潜力.

关键词:
E3 无处不在的合酶分子粘剂降解剂 分子粘剂降解剂化学生物学 化学生物学合理的设计理性的设计.有针对性的蛋白质降解降解.

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Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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