对从未吸烟者进行肺癌查:目前的证据和未来的方向
1Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore.
Singapore medical journal
|January 19, 2024
概括
从未吸烟者肺癌查在一般人群中显示低检测率,但对于具有特定风险因素的人可能是有效的. 需要进一步的研究来优化查策略和评估结果.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 低剂量计算机断层扫描 (LDCT) 是为吸烟者的肺癌查而建立的.
- 肺癌查在从未吸烟者中的有效性仍然不确定.
研究的目的:
- 评估肺癌查在从不吸烟的人群中的有效性.
- 分析未选和选定的从未吸烟者中的检测率和积极预测值.
主要方法:
- 对13项对未经选择的从未吸烟者的研究和3项对选定的从未吸烟者的研究进行了审查.
- 对肺癌检测率和积极预测值的分析.
主要成果:
- 没有选择的从未吸烟者:检测率为0.1%-1.1%,积极的预测值为0.4%-4.5%.
- 选择从未吸烟者 (石棉,,家族病史):检测率为0.3%-2.6%,积极预测值为0.7%-15%.
- 80%-100%的检测到的肺癌是早期的.
结论:
- 在选择的从未吸烟者中进行肺癌查可能会产生与高风险的从未吸烟者相比较的检测率.
- 需要进一步的研究,以获得最佳的受试者选择,替代查方法和临床/经济结果的评估.
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