低标位组O全血和RhD异免疫接种风险:在芬兰使用的理由
Sanna Susila1,2, Minna Ilmakunnas1,3,4, Jouni Lauronen1
1Finnish Red Cross Blood Service, Vantaa, Finland.
Transfusion
|January 19, 2024
概括
在芬兰,因RhD阳性低滴定量O组全血 (LTOWB) 输血而患胎儿和新生儿溶血性疾病 (HDFN) 的风险很低. 有效的查和HDFN治疗支持在紧急情况下使用LTOWB.
科学领域:
- 紧急医疗 紧急医疗
- 输血医学 输血医学
- 产科和妇科 产科和妇科
背景情况:
- 在医院前使用RhD阳性低位数组O全血 (LTOWB) 治疗出血正在增加.
- RhD 与免疫接种可以导致胎儿和新生儿 (HDFN) 的溶血性疾病.
研究的目的:
- 为了估计芬兰医院前LTOWB输血中HDFN的风险.
- 评估在医院前使用 RhD 阳性 LTOWB 的安全性.
主要方法:
- 从坦佩雷和赫尔辛基大学医院地区的医院前输血中收集的数据.
- 来自创伤研究的同免疫率被用来估计HDFN风险.
- 风险被推断为整个芬兰人口.
主要成果:
- 据估计,由于医院前的LTOWB,每十年有1-3例严重的HDFN.
- 由LTOWB诱导的HDFN导致的胎儿死亡估计不到每百年一次.
- 风险与之前的国际估计相比较.
结论:
- 在芬兰,从医院前的LTOWB中发生严重的HDFN的风险很低.
- 常规的母体查和有效的HDFN治疗可以减轻风险.
- 支持所有患者继续在医院前使用RhD阳性LTOWB.
相关概念视频
01:19Rh Blood Group
1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K
02:45Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
01:15Blood Transfusion
562
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
562
01:10Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K