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双相情感障碍妇女的使用和骨健康:一个横截面研究
Lana J Williams1,2, Bruno Agustini1, Amanda L Stuart1
1Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Acta psychiatrica Scandinavica
|January 19, 2024
概括
双相情感障碍妇女使用与明显更高的骨矿物质密度 (BMD) 和低骨质量的风险降低有关. 需要进一步的研究来了解背后的机制.
科学领域:
- 骨健康与精神病学
- 对骨完整性的药理学影响
背景情况:
- 精神疾病及其治疗可能会对骨健康产生负面影响.
- 新出现的证据表明,可能对骨有保护作用.
- 在患有双相情感障碍的女性中,对骨的影响需要进行调查.
研究的目的:
- 检查在被诊断患有双相情感障碍的妇女中,使用与骨矿物质密度 (BMD) 之间的关联.
- 评估使用与这种患者群体中低骨质量的患病率之间的关系.
主要方法:
- 从澳大利亚东南部招募了117名患有双相情感障碍的女性.
- 使用双能X射线吸收计评估骨矿物质密度 (BMD).
- 利用线性和逻辑回归来分析使用,骨质量和低骨质量之间的关联,调整混因素.
主要成果:
- 使用的女性 (29.9%) 与非使用者相比,在脊椎 (5.1%大) 和全部 (4.2%大) 的平均骨髓质量显著更高.
- 使用者表现出更高的全身 BMD (2.2%更大) 的趋势.
- 使用者的骨质量较低的可能性显著降低 (22.9%对43.9%).
结论:
- 双相情感障碍妇女使用与改善骨矿物质密度有关.
- 在这种人群中,治疗似乎可以降低患低骨质量的风险.
- 建议进一步研究的骨保护作用背后的机制.
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