一年残疾轨迹和长期心血管事件,复发性中风和缺血性中风后的死亡率
Jigang Du1,2, Yujia Zhai1, Wenjing Dong1
1Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College of Soochow University Suzhou China.
Journal of the American Heart Association
|January 19, 2024
概括
缺血性中风后的功能性残疾轨迹预测了未来的健康结果. 患有持续严重残疾的患者面临更高的心血管事件和死亡风险.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 脑卒中患者表现出不同的功能障碍水平和恢复模式.
- 脑卒中后残疾变化的预测价值仍未得到充分研究.
研究的目的:
- 描述1年的功能性残疾轨迹后缺血性中风.
- 评估这些轨迹与24个月临床结果之间的关联.
主要方法:
- 利用了CATIS试验中3533名缺血性中风患者的数据.
- 采用基于群体的轨迹建模来识别残疾模式 (修改的兰金尺度).
- 应用考克斯回归来分析与心血管事件和死亡率的关联.
主要成果:
- 确定了四种不同的残疾轨迹:没有残疾,轻微到恢复,严重到中度,持续严重的残疾.
- 持续严重的残疾与显著更高的心血管事件风险 (HR 2.63),复发性中风 (HR 2.55) 和全因死亡率 (HR 6.10) 相关.
- 严重到中度残疾也与心血管事件 (HR 1.99) 和复合结果 (HR 1.85) 的增加有关.
结论:
- 12个月内的中风后功能残疾轨迹是24个月不良结果的重要预测因素.
- 患有持续严重或严重至中度残疾的患者表现出心血管事件和死亡率的风险较高.
相关概念视频
Ischemic Heart Disease: Overview
1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Actuarial Approach
79
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
79
Exercise and Cardiovascular Response
815
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
815
Psychoneuroimmunology: Cardiovascular Disease
31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
31


