在高血压人口中,甘油三糖指数和抑郁症之间的关联
Xin Zhang1, Dan Zhao1, Shanshan Guo1
1Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
甘油三糖 (TyG) 指数与高血压成年人的抑郁症风险更高有关. 这种非线性关联在肥胖个体中尤为明显,突出了严重的健康问题.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 精神病学是一个精神病学.
背景情况:
- 高血压和抑郁有着双向的关系,这增加了这两种疾病的风险.
- 高血压患者的甘油三指数 (TyG) 和抑郁症之间的关联尚未得到充分证实.
研究的目的:
- 在高血压人口中调查TyG指数和抑郁症之间的关系.
- 探索潜在的非线性关联,并确定转折点.
主要方法:
- 采用国家健康和营养检查调查 (2007-2018) 数据进行的横截面研究.
- 使用了加权多重逻辑回归和通用添加模型.
- 一个递归算法确定了两部分线性回归模型的拐点.
主要成果:
- 分析了5897个人的队列.
- 患有抑郁症的风险增加与高血压成年人的TyG指数较高有关 (OR: 1.32,95% CI: 1.12-1.54).
- 观察到非线性关联,在TyG指数拐点为8.7 (OR: 1.44,95%CI: 1.15-1.79) 后,风险显著增加.
- 在TyG指数和肥胖之间发现了显著的相互作用.
结论:
- 甘油三糖 (TyG) 指数显示,在患有高血压的美国成年人中,与抑郁症有非线性关联.
- 研究结果表明,高TyG指数是该人群中抑郁症的独立风险因素,特别是在转折点之后.
- 肥胖可能会改变这种关系,需要进一步调查.
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