延迟内镜检查的患者中与连续性八类药物相关的水出血的结果
Matthew B Laws1, Rebekah Wahking1, Erin Blackburn1
1Department of Pharmacy, University of Kentucky HealthCare, Lexington, KY, USA.
Journal of pharmacy practice
|January 19, 2024
概括
扩展的前内镜性奥克特胺可能会减少患有食道水出血的患者的再出血. 这项研究发现,在内镜检查前使用较长时间的奥克特里奥蒂德与术后更低的复出出血率有关.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 腹出血需要及时进行内镜治疗和八胺治疗.
- 延迟内镜检查可能导致长时间的前内镜性八二胺的使用.
- 为管理出血风险,优化八胺的持续时间至关重要.
研究的目的:
- 评估扩展前内镜性八二对再出血率的影响.
- 为了比较短期和长期的后内镜性八胺治疗之间的结果.
- 为了评估奥克胺在治疗食道水出血与延迟干预中的作用.
主要方法:
- 成年肝硬化患者患有水出血的回顾性队列研究.
- 患者在内镜检查前接受了≥12小时的奥克提德.
- 群体根据内镜后的八基质持续时间定义:≤48小时 (短) 与>48小时 (标准).
主要成果:
- 分析了169名患者;88名患者接受了短期治疗,81名患者接受了标准疗程的内镜后八二.
- 在短食组中,33%的患者出现了再出血,而在标准食组中,这一比例为53.1%.
- 标准疗程组的复出出血风险明显更高 (OR 2.3,P = .008).
结论:
- 在延迟内镜检查的情况下,延长前内镜性八二胺的使用可能有助于防止再次出血.
- 需要进行进一步的研究,以确定不同出血风险和延迟干预的最佳八丁胺持续时间.
- 这表明,当内镜干预不立即时,使用较长时间的八二可能有潜在的益处.
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