在患有血清性尿素综合征的儿科患者中,自主活动和心血管系统风险评估
Derya Duman1, Serra Sürmeli Döven2, Derya Karpuz3
1Faculty of Medicine, Department of Pediatric Cardiology, Mersin University, 34. Cadde, Ciftlikkoy Kampusu, 33343, Mersin, Turkey. drderyaduman@gmail.com.
European journal of pediatrics
|January 19, 2024
概括
患有血溶性尿素综合征 (HUS) 的儿科患者表现出心率变异性 (HRV) 损伤,表明自主神经系统功能障碍. 这种非侵入性HRV评估表明,HUS患者心血管事件和心律失常的风险可能增加.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 自主神经系统功能 自主神经系统功能
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 血溶性尿性综合征 (HUS) 主要影响血液学和脏的参数.
- 二次性心肌病,高血压和功能衰竭是HUS的潜在并发症.
- 关于HUS患者自主功能和心律失常风险的数据有限.
研究的目的:
- 评估儿科HUS患者的心率变化 (HRV) 和心电图 (ECG) 发现.
- 为了比较HUS患者和健康对照组之间的HRV和ECG参数.
- 评估在HUS.中自主功能障碍和功能衰竭严重程度之间的关系.
主要方法:
- 使用24小时霍尔特心电图测量HRV参数进行非侵入性评估.
- 电心电图 (ECG) 和心声查用于心脏评估.
- 在25名HUS患者和51名健康对照者之间比较HRV,心电图发现和实验室值.
主要成果:
- 与健康对照组相比,HUS患者的HRV参数显著受损.
- 在正常到正常间隔的标准偏差,5分钟RR间隔标准偏差的平均值,5分钟RR间隔平均值的标准偏差,正常到正常间隔的三角插曲和非常低频功率中观察到显著差异.
- 脑电图的结果显示,HUS患者的PR距离减少,QT和QT分散度增加. HRV值与增加的功能衰竭参数负相关.
结论:
- 儿科HUS患者可能会经历自主神经系统功能障碍.
- 心率变化 (HRV) 作为一种有价值的非侵入性工具,用于评估HUS的自主功能.
- 在HUS患者中,心血管事件和心律不整的可能性增加,需要进行心电图查和密切监测.
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