在类风湿性关节炎中循环粘附分子的系统审查和元分析
Arduino A Mangoni1,2,3, Angelo Zinellu4
1Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia. arduino.mangoni@flinders.edu.au.
概括
与对照人群相比,类风湿性关节炎 (RA) 患者的关键细胞粘附分子水平较高,包括细胞间粘附分子-1 (ICAM-1) 和血管细胞粘附分子-1 (VCAM-1). 这些发现表明它们在RA和动脉样硬化之间的联系中的作用.
科学领域:
- 风湿病学中的生物标志物
- 炎症性疾病中的心血管风险
- 内皮功能和动脉样硬化
背景情况:
- 类风湿性关节炎 (RA) 与动脉样硬化风险增加有关.
- 确定内皮细胞激活的可靠生物标志物对于检测RA患者的亚临床动脉样硬化至关重要.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析RA患者细胞粘附分子的循环度.
- 研究细胞粘附分子作为内皮激活和亚临床动脉样硬化在RA中的生物标志物的潜力.
主要方法:
- 在2023年7月31日之前,对电子数据库进行了系统的搜索.
- 包括在内的病例控制研究测量了RA患者和对照者的免疫球蛋白类粘附分子 (ICAM-1,VCAM-1,PECAM-1) 和选择蛋白 (E,L,P).
- 使用JBI检查清单和GRADE评估了偏见风险和证据确定性.
主要成果:
- 与对照组相比,RA患者的ICAM-1,VCAM-1,PECAM-1,E-selectin和P-selectin度显著更高.
- 在RA患者和对照人群之间,L-选择素水平没有显著差异.
- 超回归显示了效果大小与葡萄糖皮质激素使用,红细胞沉积率,研究大陆和评估矩阵之间的关联.
结论:
- 细胞粘附分子在RA和动脉样硬化之间的相互作用中发挥着重要作用.
- 需要进一步的研究来确认这些生物标志物的常规使用是否可以帮助在RA中早期检测和治疗动脉样硬化.
- 普罗斯佩罗的注册号码是CRD42023466662. 这是一个很好的方法.
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