恶性疾病中的贫血诊断和治疗:指南的实施 - - 一项代表性研究
Hartmut Link1,2, Markus Kerkmann3,4, Laura Holtmann3,4
1Internal Medicine, Hematology and Medical Oncology, D-67661, Kaiserslautern, Germany. hlink@kabelmail.de.
概括
癌症贫血的诊断和治疗往往缺乏遵循指导方针. 不充分的评估和高的输血率凸显了在瘤学中改善贫血管理的需要.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 贫血是癌症患者常见的并发症.
- 遵守贫血诊断和治疗的临床指南对于有效的患者管理至关重要.
- 本研究评估了德国的指导方针实施情况.
研究的目的:
- 分析欧洲医学瘤学会 (ESMO) 和德国癌症贫血指南的实施情况.
- 评估遵守指南对癌症患者贫血纠正的影响.
- 确定贫血管理方案需要改进的领域.
主要方法:
- 对患有贫血 (等级≥2) 的癌症患者进行了回顾性流行病学研究.
- 为诊断 (GLAD-D) 和治疗 (GLAD-T) 制定和应用指南依从度评分 (GLAD).
- 分析患者数据,包括血红蛋白水平,铁状况和治疗干预措施.
主要成果:
- 分析了1046名患者;85.9%的患者在诊断时Hb水平为8-10 g/dL.
- 只有19%的患者评估了转林和度.
- 36.6%的输血缺乏指导方针指导的适用性;铁和红质形成刺激剂 (ESA) 疗法未得到充分利用.
- 更高的诊断依从性 (GLAD-D) 与更好的治疗依从性 (GLAD-T) 相相关.
- 完整的治疗依从性 (GLAD-T=2) 导致Hb增加显著更大,与部分或没有依从性相比.
结论:
- 癌症贫血的评估往往是不充分的.
- 红细胞 (RBC) 输血率过高.
- 铁和ESA疗法未得到充分使用,这表明缺乏最佳的贫血管理实践.
更多相关视频
07:24A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
1.7K
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
29.4K
相关概念视频
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Bone Marrow Sampling and Transplants
332
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
332
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
