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下垂体女性的雄激素缺乏:其后果和管理
Daniela Esposito1,2, Åsa Tivesten3,4, Catharina Olivius4,5
1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 8, Gothenburg, 41345, Sweden. daniela.esposito@gu.se.
Reviews in endocrine & metabolic disorders
|January 19, 2024
概括
患有低垂体症的女性经常经历雄激素缺乏症. 雄激素替代疗法对骨健康和身体组成有潜在的益处,但需要更多的研究来确定长期的安全性和有效性.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
背景情况:
- 患有下垂体症的女性经常表现出雄激素缺乏症,特别是那些患有性性和二次上腺功能不全的女性.
- 雄激素缺乏症的临床影响和这些女性的替代疗法的疗效仍然不完全理解.
研究的目的:
- 审查当前关于女性缺少雄激素的证据,以hypopituitarism.
- 评估在这个人群中使用雄激素替代疗法的潜在好处和风险.
主要方法:
- 对研究雄激素缺乏症和低位症妇女的替代疗法的文献综述.
- 分析有关骨矿物质密度,生活质量,性功能和身体组成的现有数据.
主要成果:
- 有限的证据表明,透皮对骨代谢和身体组成有潜在的益处.
- 口服脱水素氨 (DHEA) 的研究显示,关于生活质量和性功能的结果各不相同.
- 缺乏关于定义雄激素缺乏症的共识,以及有限的长期安全数据,阻碍了治疗指南.
结论:
- 雌激素缺乏症在患有下垂体症的女性中很常见,但其确切的影响和最佳管理尚不清楚.
- 虽然一些研究表明雄激素替代治疗的潜在益处,但进一步的研究对于确定长期有效性和安全性至关重要.
- 在这种患者群体中,建议采取个性化和谨慎的方法来管理雄激素缺乏症.
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