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血清IL-2和Th17/Treg不平衡升高与痛风有关

Xiaoyu Zi^1,2, Ronghui Su^1,2, Rui Su^1,2

¹Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Clinical and experimental medicine

|January 19, 2024

概括

痛风的发病包括免疫系统的不平衡. 这项研究在早期和晚期发病的痛风中发现了明显的T辅助17 (Th17) 和T调节 (Treg) 细胞差异,分别突出了T17升高和Treg细胞降低,影响了痛风的进展.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
自发炎性疾病自发炎性疾病

背景情况:

痛风是一种自身炎症性疾病,免疫驱动因素不完全理解.
了解T辅助17 (Th17) 细胞,T调控 (Treg) 细胞和细胞因子的作用对于阐明痛风病原性至关重要.

研究的目的:

为了比较外围淋巴细胞和CD4+T细胞子集,以及痛风患者和健康对照者的细胞因子.
探索Th17细胞,Treg细胞和细胞因子对痛风发病的特定贡献,区分早期和晚期发病的痛风.

主要方法:

使用流细胞计量来量化外围淋巴细胞和CD4+T细胞亚群.
使用流量细胞计数珠阵列测量血清细胞因子水平.
进行了接收器运行特征 (ROC) 分析,以评估对托菲斯形成的预测性能.

主要成果:

与健康对照组相比,在早期发病的痛风,晚期发病的痛风和没有托菲斯的痛风中观察到更高的Th17/Treg比率.
早期发病的痛风显示Th17细胞升高,而晚期发病的痛风显示Treg细胞减少.
痛风患者表现出显著更高的各种细胞因子水平,包括IL-2,IL-4,IL-6,IL-10,IL-17,IFN-γ和TNF-α.

结论:

早期和晚期发病的痛风表现出明显的Th17/Treg不平衡,由早期发病的Th17细胞升高和晚期发病的痛风中的Treg细胞降低所驱动.
血清细胞因子水平的增加,特别是IL-2,与痛风的发病有关.
恢复Th17/Treg平衡为改善痛风患者预后提供了一个潜在的治疗策略.

关键词:

早期发病的痛风是什么在IL-2中,IL-2被认为是IL-2.晚期发生的痛风.监管性T细胞监管性T细胞辅助性T细胞17细胞

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