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Updated: Aug 1, 2026

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通过基于组合的虚拟查方法,分子动力学模拟和体外生物活性测试发现新型Akt1抑制剂

Wen Zhang1, Mei-Ling Hu1, Xiu-Yun Shi1

  • 1College of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.

Molecular diversity
|January 19, 2024
PubMed
概括

研究人员确定了一种新型化合物Hit9,作为Akt1 (也称为蛋白激酶B) 的强有力的抑制剂,这是癌症治疗的关键标. 这一发现为开发有效的癌症治疗提供了一个有希望的新途径.

关键词:
这是一个3D-QSAR模型.这是一种Akt1抑制剂.生物活动是生物活动.深度学习模型深度学习模型分子动力学分子动力学药科类型的模型.

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