适应式伺服通风对生活质量的影响:READ-ASV注册表
Michael Arzt1, Oliver Munt2, Jean-Louis Pépin3
1Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
适应性伺服通风 (ASV) 显著改善生活质量,并减少中心睡眠呼吸暂停 (CSA) 和阻塞性睡眠呼吸暂停 (OSA) 患者的白天嗜睡. 在接受ASV治疗的有症状个体中,改善最为显著.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 临床试验 临床试验
背景情况:
- 适应性伺服通风 (ASV) 是对睡眠呼吸障碍 (SDB) 的一种成熟的治疗方法.
- 中央睡眠呼吸暂停 (CSA) 和阻塞性睡眠呼吸暂停 (OSA) 是SDB的常见形式.
- 在改善生活质量 (QoL) 方面,ASV的有效性需要在现实环境中进一步调查.
研究的目的:
- 为了评估首次ASV治疗对CSA患者的疾病特异性QoL的影响,有或没有OSA.
- 作为次要结果,评估白天嗜睡的变化.
- 确定从ASV治疗中受益最多的患者子组.
主要方法:
- 未来的多中心欧洲注册 (READ-ASV) 登记了801名患有CSA +/- OSA的成年人.
- 主要终点:12个月后睡眠问卷 (FOSQ) 的功能性结果得分的变化.
- 二级终点:爱普沃思睡眠度量 (ESS) 评分的变化;对有症状与无症状患者的亚组分析.
主要成果:
- 在12个月后,ASV治疗显著改善了FOSQ得分 (中位数增加+0.8,P<0.001).
- 与无症状患者 (+0.11) 相比,有症状的患者在FOSQ分数 (+1.69) 中表现出更大的改善.
- 白天睡眠也显著改善,ESS得分的中位数下降为-2.0 (P < 0.001).
结论:
- 在患有CSA +/- OSA的患者中,ASV治疗与QoL显著改善和白天嗜睡减少有关.
- 患有SDB预先存在的症状的患者经历了ASV的最实质性的好处.
- 这些发现支持使用ASV来治疗有或没有OSA的CSA,特别是在有症状的个体中.
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