脂质特征与冠状动脉疾病和死亡率的剂量反应关联
Guoyi Yang1,2, Amy M Mason3,4, Angela M Wood3
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
JAMA network open
|January 19, 2024
概括
阿波蛋白B (apoB) 和LDL-C与冠状动脉疾病 (CAD) 和死亡率的更高风险有关. 三甘油 (TG) 也可能增加CAD风险,但它们与死亡率的关联不太清楚.
科学领域:
- 心血管遗传学 心血管遗传学
- 脂质代谢 脂质代谢是什么
- 流行病学 流行病学
背景情况:
- 阿波蛋白B (apoB),低密度脂蛋白胆固醇 (LDL-C) 和甘油三 (TG) 是冠状动脉疾病 (CAD) 的确立危险因素.
- 然而,最终的试验证据将密集的降脂策略与死亡率益处联系起来仍然不那么有说服力.
研究的目的:
- 研究基因预测的apoB,LDL-C和TG与CAD和死亡率之间的关联.
- 为了检查这些协会跨不同性别和年龄组.
- 描述这些关联的形状,包括潜在的非线性关系.
主要方法:
- 使用线性和非线性孟德尔随机化 (MR) 分析.
- 雇佣了来自英国生物银行 (UK Biobank) 的大量基于人口的队列 (347,797名参与者).
- 使用后勤和考克斯回归模型评估与CAD的关联,所有原因死亡率和特定原因死亡率.
主要成果:
- 基因预测的apoB和LDL-C显示了与CAD,全因死亡率和心血管死亡率的积极关联,以剂量依赖的方式.
- 基因预测TG与CAD相关,但其与死亡率结局的关联在调整apob后减少,表明潜在的pleiotropy.
- 非线性MR表明,所有脂质关联在它们的分布中均地增加,在较低的水平上没有减少,无论性别或年龄.
结论:
- 降低ApoB (或相当于LDL-C) 降低对于降低整个分布的心血管疾病和死亡率至关重要.
- 三甘油可以独立于apoB对CAD风险作出贡献,尽管需要考虑pleiotropy.
- 这些发现强化了管理apoB/LDL-C水平对心血管健康的重要性.
更多相关视频
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.3K
08:45LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
13.4K
相关概念视频
01:31Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K
01:03Dose-Response Relationship: Overview
3.1K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.1K
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
664
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
664
01:18Lipids: Dietary Sources and Requirements
744
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
744
01:22Dose-Response Relationship: Potency and Efficacy
4.4K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.4K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
164
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
164