在三个前性队列中,虚弱和发生心血管疾病的变化
Di He1, Zhaoping Wang1, Jun Li1
1Department of Epidemiology and Biostatistics, and Department of Respiratory Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, China.
European heart journal
|January 19, 2024
概括
虚弱状态的进展显著增加了心血管疾病 (CVD) 的风险,而从虚弱状态恢复降低了心血管疾病风险. 随着时间的推移,脆弱性的变化对于预测发生的心血管疾病至关重要.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 虚弱是心血管疾病 (CVD) 的已知危险因素.
- 以前的研究集中在基线脆弱性,忽视了随时间的变化.
- 了解脆弱动态对于准确的心血管疾病风险评估至关重要.
研究的目的:
- 调查脆弱状态的变化与心血管疾病发病率之间的关联.
- 分析脆弱性进展和恢复如何影响心血管疾病风险.
- 为预防心血管疾病提供有关动态脆弱性评估的见解.
主要方法:
- 利用了来自三个大型前队伍的数据:CHARLS,ELSA和HRS.
- 使用洛克伍德脆弱指数评估脆弱性 (坚固,前脆弱,脆弱).
- 分析了基线和2年随访期间虚弱状态的变化,与使用Cox模型的事件CVD相关.
主要成果:
- 从强壮状态向前脆弱/脆弱状态的进展增加了心血管疾病风险 (HRs从1.53到1.84).
- 从脆弱状态恢复到强壮/脆弱前状态降低了心血管疾病风险 (HRs从0.49到0.70不等).
- 从前脆弱状态恢复到强壮状态也降低了心血管疾病风险 (HRs从0.65到0.71).
结论:
- 虚弱状态的变化显著影响了发生事件心血管疾病的风险.
- 脆弱性进展会增加心血管疾病的风险,而脆弱性恢复会减轻风险.
- 对脆弱性的动态评估对于预测和潜在地预防心血管事件至关重要.
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