空气污染物,遗传易感性和腹腔大动脉瘤风险:一项前性研究
Yudiyang Ma1,2, Dankang Li1,2, Feipeng Cui1,2
1Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
长期暴露于PM2.5和NO2等空气污染物增加了腹腔大动脉瘤 (AAA) 的风险. 即使是低水平的暴露也会带来风险,强调需要更清洁的空气来预防心血管疾病.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染物是心血管疾病的确立危险因素.
- 长期暴露于空气污染物和腹腔大动脉动脉瘤 (AAA) 风险之间的特定关联在很大程度上是未知的.
- 了解这种联系对于针对心血管健康的公共卫生倡议至关重要.
研究的目的:
- 调查长期暴露于环境空气污染物和腹腔大动脉动脉瘤 (AAA) 的发生率之间的关联.
- 评估各种空气污染物,包括颗粒物和氧化对AAA风险的影响.
- 探索空气污染物暴露和遗传倾向对AAA发展的综合影响.
主要方法:
- 利用了449,463名参与者的英国生物库数据.
- 采用了Cox比例危险模型,使用时间变化的暴露数据来估计AAA发病率的危险比率.
- 应用精细和灰色回归来计算累积AAA发生率和分析基因环境相互作用.
主要成果:
- 长期暴露于PM2.5,PM10,NO2和NOx与AAA的风险增加显著相关.
- 即使在低水平的空气污染物暴露时也观察到有害影响.
- 暴露于高空气污染物和高遗传风险的个人表现出相当高的AAA风险,风险估计范围为2.01至3.18.
结论:
- 长期暴露于常见的空气污染物与腹腔大动脉动脉瘤的发病率较高有关.
- 空气污染是AAA的重要危险因素,独立于遗传倾向.
- 研究结果强调了空气质量对心血管健康和AAA预防的重要性.
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