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Updated: Jun 17, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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广泛中和抗体VRC01的预防有效性取决于HIV-1包膜序列特征

Michal Juraska1, Hongjun Bai2,3, Allan C deCamp1

  • 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109.

Proceedings of the National Academy of Sciences of the United States of America
|January 19, 2024
PubMed
概括

对HIV-1序列的基因型选分析显示,在获得的HIV-1菌株中VRC01表位的距离与VRC01广泛中和抗体 (bnAb) 的预防疗效相关. 这一发现有助于预测bnAb对HIV-1的有效性.

关键词:
艾滋病毒多样性 艾滋病毒多样性击距离 击距离 击距离一个PAR得分的得分是PAR.标志性 标志性 标志性 标志性子分析分析 子分析

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