奥西默提尼布诱导的严重双侧肺胸部:一个病例报告
He Li1, Xiaojuan Shi, Gang Chen
1Department of Respiration, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Medicine
|January 19, 2024
概括
治疗EGFR突变NSCLC的奥西默提尼布可以导致罕见但致命的双侧肺胸. 这种表现为咳和胸部紧张的不良事件可能在患有先前存在的呼吸道疾病的患者中更常见.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 奥西默提尼布是一种第三代EGFR-TKI标准,用于高级NSCLC,特别是脑转移.
- 它改善了EGFR突变NSCLC患者的无进展和整体存活率.
- 像双边肺胸炎这样的罕见不良事件的潜在死亡率需要进一步调查.
研究的目的:
- 为了调查双边肺胸炎的发生和潜在的致命性,作为与 osimertinib 治疗的患者的不良事件.
- 为了突出 osimertinib 与严重的肺部并发症之间的关联.
主要方法:
- 一份病例报告显示,一名72岁的男性患有IV期NSCLC和EGFR突变 (21L858R),接受了osimertinib治疗.
- 在 osimertinib 治疗期间对不良事件的监测.
- 在发生间歇性肺病和肺胸病时,停止服用奥西默蒂尼布,开始服用普得尼索隆和支持性护理.
主要成果:
- 患者在开始服用 osimertinib 药物后大约 10 周出现了严重的间歇性肺病和双边肺胸.
- 最初的症状包括严重的咳和胸部紧张.
- 双边肺胸对治疗不耐药,导致患者死亡.
结论:
- 奥西默提尼布可以诱导严重且可能致命的双侧肺胸,即使在没有先前呼吸道疾病的患者中也是如此.
- 在患有潜在呼吸道疾病的患者中,风险可能会增加.
- 早期识别咳和胸部紧张等症状对于管理这种罕见但严重的不良事件至关重要.
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