针对高级恶性结膜瘤的向治疗和免疫治疗:系统性审查
Kubra Serbest Ceylanoglu1,2, Buse Guneri Beser1, Tassapol Singalavanija1,3
1Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, U.S.A.
Ophthalmic plastic and reconstructive surgery
|January 19, 2024
概括
向治疗和免疫疗法对晚期结膜瘤,包括状细胞癌,黑色素瘤和淋巴瘤有前途. 这些治疗提供了显著的响应率,在许多不同瘤类型的患者中观察到完全响应.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 医学研究 医学研究
背景情况:
- 先进的结膜瘤,如状细胞癌,黑色素瘤和淋巴瘤,存在重大治疗挑战.
- 对于这些罕见的恶性瘤,现代全身疗法的疗效数据有限.
- 了解向治疗和免疫治疗的结果对于改善患者护理至关重要.
研究的目的:
- 系统地审查针对性治疗和免疫治疗在晚期结膜瘤患者的结果.
- 评估结膜状细胞癌,结膜黑色素瘤和结膜淋巴瘤的治疗反应.
主要方法:
- 从1999年1月到2022年12月,在Pubmed数据库中进行了系统的文献搜索.
- 包括以英语出版的研究.
- 分析了42篇关于晚期恶性结膜瘤的文章中的142名患者的数据.
主要成果:
- 结膜状细胞癌通过表皮生长因子受体抑制剂得到改善,通过全身免疫疗法获得高响应率 (72%的完整响应).
- 结膜黑色素瘤对BRAF/MEK抑制剂 (33%CR) 和免疫治疗 (28%CR) 的反应不同.
- 结膜淋巴瘤在系统性Rituximab (63%) 和内伤性Rituximab (75%) 的治疗中实现了高的完全响应率.
结论:
- 向治疗和免疫疗法在治疗晚期恶性结膜瘤方面表现出令人鼓舞的疗效.
- 尽管病例报告和随访时间有限,但这些新的治疗方法具有显著的潜力.
- 进一步的研究是有必要的,以优化治疗策略和这些罕见的眼睛癌症的长期结果.
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