儿科加密球菌病 儿科加密球菌病
Alison Gifford1, Naamal Jayawardena1, Fabianne Carlesse2,3
1MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom.
The Pediatric infectious disease journal
|January 19, 2024
概括
儿童,特别是艾滋病毒感染儿童的加密球菌病带来了独特的挑战. 本综述强调了各种临床症状,结果和治疗差异,强调了需要进一步研究的必要性.
科学领域:
- 儿童传染病 儿童传染病
- 菌类学 菌类学是指菌类学.
- 流行病学 流行病学
背景情况:
- 加密球菌是艾滋病毒感染个体脑膜炎的常见原因,但儿童疾病的报道不足.
- 血清流行率表明儿童的广泛暴露,与报告的疾病发病率较低形成鲜明对比.
研究的目的:
- 进行对儿科加密菌病的全面审查.
- 分析基于免疫状态的临床表现,结果和治疗模式.
主要方法:
- 在PubMed和Ovid全球健康数据库的系统文献搜索.
- 包括1980年至2022年12月期间报告儿科数据的英语研究.
- 综述了168份涉及1469名儿童的出版物.
主要成果:
- 大多数病例 (54.2%) 来自非洲;65%的儿童是艾滋病毒阳性.
- 发烧,头痛和吐是常见的症状;80%的人患有脑膜炎.
- 肺部感染因免疫状况而异;只有22%的人接受了推的联合抗真菌疗法.
- 总体死亡率为23%,HIV阳性儿童的死亡率更高.
结论:
- 这一综述是关于儿科加密球菌病的最大综述,揭示了明显的临床特征和结果.
- 基于潜在的疾病,特别是艾滋病毒,治疗和结果存在显著差异.
- 迫切需要进行前性研究,以提高对儿科加密菌病的理解和管理.
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