在一个早产新生儿中发生了与肠球菌专利管道动脉关联的内关节炎的病例
Alessandra Mayer1, Beatrice Letizia Crippa1, Carlo Pietrasanta1,2
1From the NICU, Mother and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
The Pediatric infectious disease journal
|January 19, 2024
概括
在早产新生儿中,与专利通道动脉相关的内关节炎正在增加. 一个高水平的氨基糖化物耐药性肠球菌感染病例成功地用安皮西林和塞福塔克西姆治疗.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 在早产新生儿中,持久的专利动脉管 (PDA) 可以导致感染性内心炎 (IE) 或在败血症期间的管道内心炎 (DE).
- 新生儿IE和DE发病率正在上升,原因是早产婴儿的生存率提高和侵入性手术的增加.
- 抗菌素耐药性是新生儿重症监护室 (NICU) 的一个日益严重的问题,需要广泛的或最后的抗生素使用.
研究的目的:
- 在早产新生儿中报告PDA相关的DE病例.
- 以突出成功治疗肠球菌IE/DE,使用特定的抗生素组合.
主要方法:
- 一个早产新生儿患有败血症的案例报告.
- 诊断与专利通道动脉相关的通道内关节炎.
- 用安皮西林和塞福塔克西姆的协同作用组合进行治疗.
主要成果:
- 新生儿经历了由高水平的氨基糖化物耐药性肠球菌引起的败血症.
- 与PDA相关的DE的成功治疗是通过安培西林和塞福塔克西姆实现的.
- 协同抗生素组合证明即使在早产婴儿中也是有效的.
结论:
- 感染性内心炎和PDA相关的DE正在NICU中增加,需要临床意识.
- 由高水平的氨基糖化物耐药菌株引起的肠球菌IE和PDA相关的DE可以在早产新生儿中有效地用安比西林和塞福胺治疗.
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