在儿童的骨盆急性血源性骨髓炎
Adriana Sarmiento Clemente1, J Chase McNeil, Kristina G Hultén
1From the Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.
The Pediatric infectious disease journal
|January 19, 2024
概括
儿童的骨盆急性血源性骨髓炎 (AHO) 并不比非骨盆的AHO更复杂. 较短的抗生素疗程可能足以选择患有盆腔AHO的儿科患者.
科学领域:
- 儿童传染病 儿童传染病
- 肌肉骨系统感染
- 临床结果研究研究的临床结果.
背景情况:
- 在儿科急性血源性骨髓炎 (AHO) 中,盆腔参与发生在3%-14%的病例中.
- 指导方针建议在盆腔AHO治疗中使用较长的抗生素疗程,但最近的数据很少.
- 本研究将骨盆AHO的临床过程与儿童的非骨盆AHO进行比较.
研究的目的:
- 为了比较儿科骨盆AHO与非骨盆AHO的临床特征和结果.
- 评估目前的骨盆AHO的治疗和并发症率.
- 为了告知小儿盆腔AHO的抗生素治疗持续时间指南.
主要方法:
- 在2012年至2020年期间入院的儿童患者 (6个月19岁) 的回顾性评估.
- 排除患有状细胞疾病或免疫性损害的患者.
- 使用威尔科克森等级和费舍尔精确测试进行骨盆 (n=104) 和非骨盆 (n=314) AHO 的比较.
主要成果:
- 与非骨盆AHO患者相比,骨盆AHO患者更频繁地患有骨髓炎 (28.8%vs9.4%) 和较少的骨 (22.1%vs46.5%).
- 微生物学,停留时间和抗生素持续时间在各组之间是相似的.
- 慢性并发症的发生率相似 (8.4%对15.1%);18.3%的盆腔AHO患者接受了≤30天的抗生素而没有并发症.
结论:
- 儿童盆腔AHO可能比以前认为的更常见,但不会导致并发症增加.
- 对于精选的患有盆腔AHO的儿科患者,四周的抗生素疗程可能足够.
- 需要进一步的前性研究来确认盆腔AHO的最佳抗生素持续时间.
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