运动和缺氧诱导的高凝血在女性中部分由血小板反应性降低抵消
M Ninivaggi1, F Swieringa2, H Middelveld3
1Department of Functional Coagulation, Synapse Research Institute, Maastricht, the Netherlands.
Thrombosis research
|January 19, 2024
概括
缺氧和运动通过影响血液凝结和血小板激活增加了血栓形成的风险. 女人表现出更为前血栓的状态,可能会被高海拔地区的血小板反应能力降低所抵消.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
- 血液学 血液学 血液学
背景情况:
- 在COPD和睡眠呼吸暂停等疾病中常见的缺氧会增加血栓形成的风险.
- 缺氧与高凝血性有关,影响血块形成.
- 了解缺氧期间对凝血的性别和运动影响对于管理健康风险至关重要.
研究的目的:
- 研究性别和运动在高海拔低氧条件下对凝血潜力的影响.
- 为了评估血栓生成 (TG) 和血小板激活,以应对高度和体力炼.
- 为了确定在急性山区暴露期间高凝血和血小板反应的性别特异性差异.
主要方法:
- 十名健康的志愿者 (50%是男性,平均年龄为27.5岁) 在海平面和高海拔 (3883米) 上进行了研究.
- 测量是在被动 (电缆车) 和主动 (徒步旅行) 上升到高海拔后进行的.
- 评估的参数包括血栓生成,血小板激活,FVIII,·维勒布兰德因子和血细胞计数.
主要成果:
- 活动上升增加了血小板,白细胞和粒细胞的数量,同时减少了淋巴细胞,没有性别差异.
- 在两种性别中,FVIII和·维勒布兰德因子显著增加了后活跃登.
- 血小板激活在高海拔地区减少和延迟,特别是在女性中,她们整体表现出更容易高凝血的表型.
结论:
- 低氧与运动相结合会增加血栓生成和FVIII和·维勒布兰德因子的水平.
- 血小板反应能力在高海拔地区下降,特别是在艰苦的运动后.
- 女性表现出更明显的原血栓现象型,在低血压条件下,可能会通过降低血小板激活来平衡.
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