布皮瓦卡因脂质体注射悬浮剂在接受腹部手术的狗中没有改善疼痛控制
Journal of the American Veterinary Medical Association
|January 19, 2024
概括
与标准阿片类药物治疗相比,布皮瓦卡因脂质体注射悬浮剂 (BLIS) 在腹部手术后的狗中没有改善术后疼痛控制. 在使用BLIS时,没有观察到短期并发症的增加.
科学领域:
- 兽医外科 兽医外科 兽医外科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 术后疼痛管理对于腹部手术后狗的恢复至关重要.
- 新的止痛技术,如局部透,正在不断探索,以提高疼痛控制.
- 布皮瓦卡因脂质体注射悬浮剂 (BLIS) 提供了长时间的局部麻醉,但其在狗腹部手术中的有效性需要评估.
研究的目的:
- 为了比较手术切口透与布皮瓦卡因脂质体注射悬浮液 (BLIS) 与液在经历腹部手术的狗中治疗术后疼痛的疗效.
- 评估BLIS对疼痛评分,生理参数和并发症率的影响.
主要方法:
- 接受探索性腹腔切除术的40只狗被前性地注册并随机选择.
- 狗在关闭期间接受了BLIS (5.3 mg/kg) 或透到手术层中的盐水.
- 经手术后的疼痛被评估使用电子算法,格拉斯哥综合测量疼痛量表 (GCMPS) 的简体版本,血压,心率和血清皮质醇水平由盲目观察员.
主要成果:
- 静脉血压在0日的盐水组显著更高 (P = .006).
- 格拉斯哥综合测量疼痛量表得分在BLIS组在第3天较低 (P = .027),尽管整体得分较低,样本大小有限.
- 在其他疼痛评估,生理参数或组之间的并发症率方面没有发现显著差异.
结论:
- 与探索性腹腔切割术后的狗中标准阿片类止痛药相比,使用BLIS进行外科切割透并没有提供优异的术后疼痛控制.
- BLIS与短期手术并发症没有增加有关.
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