检查患有或没有青素过敏标签的患者的塞法林利用率和术后过敏:一个横截面研究
Zachary R Murphy1, Anum F Muzaffar2, Sandra A Massih3
1Department of Anesthesiology, University of Michigan, Ann Arbor, MI, United States of America.
Journal of clinical anesthesia
|January 19, 2024
概括
塞法林外科手术期过敏反应 (POA) 是罕见的,在有或没有青素过敏标签 (PAL) 的患者之间没有显著差异. 这表明塞法林是PAL患者的安全预防选择.
科学领域:
- 麻醉学和外科手术期间的医学.
- 临床药理学 临床药理学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 青素过敏标签 (PALs) 是常见的,往往导致避免使用β-乳糖抗生素,如cefazolin.
- 在PAL患者中,与塞法林相关的术后过敏症 (POA) 的实际发病率尚未得到充分确立.
- 了解这种风险对于优化外科手术期间抗生素选择至关重要.
研究的目的:
- 为了比较切法林POA在手术患者中发生的情况,有和没有PAL.
- 为了确定塞法林POA的患病率是否根据PAL的存在而有所不同.
- 评估PAL患者中使用塞法林的趋势.
主要方法:
- 在2017年7月至2020年7月期间,对112,817次手术的截面研究.
- 鉴定了使用试酶序列或二胺管理的潜在POA病例.
- 通过过敏反应文档和专家过敏专家审查验证的POA.
主要成果:
- 塞法林POA的总体患病率为0.02%.
- 只有一个塞法林POA病例 (在22个POA病例中) 具有PAL,在PAL患者和无PAL患者之间的POA患病率没有显著差异 (p=0.437).
- 在PAL患者中,外科手术期间使用塞法林的比例在2017年至2020年间从2.6%增加到6.0%.
结论:
- 塞法林POA的患病率很低,在患有PAL和没有PAL的患者之间没有显著差异.
- 塞法林可以被认为是PAL患者可接受的预防方案.
- 目前的数据支持重新考虑仅基于PAL的全面抗生素规避.
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