围产期暴露和青春期超重:母子共享路径的作用
Ilona Shapiro1, Iaroslav Youssim1, Ora Paltiel1
1Braun School of Public Health, Hebrew University of Jerusalem, Jerusalem, 99112102, Israel.
Atherosclerosis
|January 19, 2024
概括
围产期暴露和产科并发症独立地影响青少年超重. 共同的母婴因素影响暴露效应,但产科并发症有独立的途径影响后代的健康.
科学领域:
- 生殖健康 生殖健康
- 儿科卫生健康 儿科卫生健康
- 流行病学 流行病学
背景情况:
- 早期生活中的暴露显著影响长期后代的健康.
- 围产因素和产科并发症是青少年健康结果的关键决定因素.
- 了解这些关联是开发有效干预措施的关键.
研究的目的:
- 调查流行围产期暴露和产科并发症与青春期后代超重的独立关联.
- 确定是否共享的母子路径调解了围产期暴露和青少年超重之间的关系.
- 阐明分娩并发症影响后代体重的不同途径.
主要方法:
- 利用来自耶路撒冷周产期研究出生队列的数据.
- 构建的"产科并发症" (OC) 和"普遍的围产期暴露" (PPE) 分数.
- 采用后勤回归来分析与后代超重的关联,调整为母亲的终生存活率.
主要成果:
- 无论是OC和PPE分数都是独立地与后代超重相关的.
- 孕产妇的存活率与后代超重有关,但这种联系被PPE得分削弱.
- 即使考虑到母亲的存活率,OC得分与后代超重的关联仍然很重要.
结论:
- 分享的母婴因子,反映在母婴生存率上,解释了流行围产期暴露对后代超重的影响.
- 产科并发症对后代超重有独立的影响,这表明了额外的贡献途径.
- 这些发现突出了围产期因素和母亲特征在塑造后代健康轨迹的复杂相互作用.
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