由于SARS-CoV-2 Omicron变异的护理和医疗保健相关的肺炎
Naoyuki Miyashita1, Yasushi Nakamori2, Makoto Ogata1
1First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Japan.
与Omicron变种相关的护理和医疗保健相关肺炎 (NHCAP) 病例显示,与社区获得的肺炎 (CAP) 相比,ICU停留和死亡率更高. 对于细菌和病毒性肺炎的管理,NHCAP至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 临界护理医学 临界护理医学
背景情况:
- 护理和医疗保健相关肺炎 (NHCAP) 的临床特征与SARS-CoV-2祖先,阿尔法和三角菌株的社区获得性肺炎 (CAP) 有所不同.
- 与之前的SARS-CoV-2变种相比,Omicron变种显示肺部感染性和病原性降低.
- 这项研究旨在阐明NHCAP和CAP之间的临床区别,特别是在Omicron变种流行期间.
研究的目的:
- 为了比较由Omicron变种引起的NHCAP和CAP的临床特征.
- 评估NHCAP对病毒性肺炎的分类的必要性,包括由SARS-CoV-2变种引起的病毒性肺炎.
主要方法:
- 对516名NHCAP和547名CAPCOVID-19肺炎患者的回顾性分析.
- 基于病因变异的NHCAP病例分类:330个Omicron (BA.1,BA.2,BA.5) 和186个非Omicron.
主要成果:
- 与CAP患者相比,与Omicron相关的NHCAP患者的中位数年龄,并发病率,ICU入院率和死亡率显着更高.
- 患有非Omicron变异的NHCAP患者比患有Omicron变异的患者有更高的ICU入院率和住院死亡率.
- 在NHCAP中,Omicron BA.1,BA.2和BA.5亚变体组之间没有发现显著的临床差异.
结论:
- 在管理病毒性肺炎方面,NHCAP分类是必不可少的,不仅仅是细菌性.
- 根据NHCAP标准的适用性,需要定制的预防和治疗策略.
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