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甲状腺激素功能障碍在MOGAD和其他脱髓化疾病中
Ariel Rechtman1, Omri Zveik1, Nitsan Haham1
1Department of Neurology and Laboratory of Neuroimmunology and the Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Medical Center, Ein-Kerem, Faculty of Medicine, Hebrew University of Jerusalem. Jerusalem, Israel.
Journal of the neurological sciences
|January 19, 2024
概括
甲状腺激素可能会影响中枢神经系统 (CNS) 脱髓化疾病,如MOGAD. 在MOGAD中较高的FT3和TSH,FT4和NMOSD中的疾病标志物之间的关联表明潜在的治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 甲状腺激素对于神经元和质细胞功能至关重要.
- 自免疫性甲状腺疾病经常与多发性硬化症 (MS) 一起发生.
- 之前的研究表明甲状腺激素和神经omyelitis optica光谱障碍 (NMOSD) 之间存在联系,但不是与髓寡细胞糖蛋白相关的脱髓化 (MOGAD).
研究的目的:
- 为了研究甲状腺激素在中枢神经系统自身免疫性脱髓化疾病中的作用.
- 为了比较患有MOGAD,NMOSD,MS和其他神经系统疾病的患者的甲状腺激素水平.
- 探索甲状腺激素水平,疾病严重程度 (EDSS) 和大脑体积之间的相关性.
主要方法:
- 分析了26名MOGAD,52名NMOSD,167名MS和16名对照患者的甲状腺激素水平 (FT3,TSH,FT4) 和临床数据 (EDSS).
- 使用磁共振成像 (MRI) 和MDbrain平台评估体积大脑信息.
- 相关的荷尔蒙水平与扩大残疾状态量表 (EDSS) 评分和大脑体积.
主要成果:
- 在MOGAD患者中,自由三甲氨酸 (FT3) 水平明显高于NMOSD患者.
- 在NMOSD患者中,高甲状腺刺激激素 (TSH) 与较低的残疾和较大的大脑体积相关.
- 在复发的MOGAD中观察到较高的自由甲状腺素 (FT4) 水平,并且与NMOSD中增加的残疾和减少的大脑体积有关.
结论:
- 甲状腺激素失调可能与MOGAD和其他中枢神经系统脱髓化疾病有关.
- 特定的甲状腺激素模式在MOGAD和NMOSD之间有所不同,这表明它们具有不同的病理生理学作用.
- 对甲状腺轴机制的进一步研究可能会揭示脱髓化疾病的新型治疗策略.
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