Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K
Genetic Lingo01:11

Genetic Lingo

102.8K
Overview
102.8K
Glaucoma: Overview01:25

Glaucoma: Overview

574
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
574
Incomplete Dominance01:43

Incomplete Dominance

22.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Increasing Evidence for the Utility of Red-Light Therapy and High Concentration Atropine in Myopia Control.

Clinical & experimental ophthalmology·2026
Same author

Genome-wide discovery reveals 30 loci for choroidal thickness and uncovers potential causal links with angle-closure glaucoma.

medRxiv : the preprint server for health sciences·2026
Same author

Prevalence of Strabismus and Decreased Stereopsis in Parents of Children with Strabismus.

Ophthalmology·2026
Same author

Multi-Ancestry, Multitrait Polygenic Risk Scores for Myopia: Improved Accuracy and Clinical Potential.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2026
Same author

Low-concentration atropine for management of myopia progression: does iris colour matter?

Eye (London, England)·2026
Same author

A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma.

Nature communications·2026

相关实验视频

Updated: Jul 5, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.3K

让绿眼病遗传研究变得更加多样化

David A Mackey1, Sandra E Staffieri2

  • 1Lions Eye Institute, University of Western Australia, Perth, WA, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Cell
|January 19, 2024
PubMed
概括

现在的绿眼病遗传研究还包括非洲的祖先, 这项研究改进了非洲祖先的多基因风险得分.

科学领域:

  • 眼科 眼科
  • 遗传学
  • 人口健康

背景情况:

  • 眼病是导致失明的主要原因,
  • 之前对玻璃眼的遗传研究基本上排除了不同种群,主要集中在欧洲祖先身上.
  • 这种差距限制了对不同祖先的青光眼遗传结构的理解.

研究的目的:

  • 专门针对非洲血统的人进行全基因组关联研究 (GWAS).
  • 在这个代表性不足的人群中识别与眼风险相关的遗传变异.
  • 将发现与欧洲祖先队列的现有GWAS数据进行比较,并完善多基因风险得分.

主要方法:

  • 在非洲祖先的群体中进行全基因组关联研究 (GWAS).
  • 对基因变异及其与青光瘤的关联进行分析.
  • 与之前在欧洲祖先GWAS中报告的确定的位点进行比较.
  • 针对非洲祖先的多基因风险评分 (PRS) 的开发和完善.

主要成果:

  • 在非洲祖先的个体中识别与眼风险相关的遗传位置.
  • 在非洲和欧洲祖先之间,与眼相关的遗传因素有显著的重叠.
  • 对多基因风险评分的改进,提高了对非洲祖先群体眼的预测准确性.

更多相关视频

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.6K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K

相关实验视频

Last Updated: Jul 5, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.3K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.6K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K

结论:

  • 为了确保公平的理解和治疗, 绿眼病的遗传研究必须优先考虑不同的祖先.
  • 在祖先之间存在共享的遗传风险因素,但祖先特定的变体也会有所贡献.
  • 改善非洲祖先的多基因风险得分可以帮助早期发现和干预青光眼.