在抗灭绝的记忆中协调大脑分布式网络活动
Charlie J Clarke-Williams1, Vítor Lopes-Dos-Santos1, Laura Lefèvre1
1Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, UK.
Cell
|January 19, 2024
概括
像驱动可卡因寻找行为一样, 牢固的记忆是由协调的大脑活动组织起来的. 具体来说,多个大脑区域的高阶β频振荡模式是记忆检索和更新的基础.
科学领域:
- 神经科学
- 行为神经科学
- 系统神经科学
背景情况:
- 持久的记忆, 尤其是那些与不适应性行为如成相关的记忆,
- 如何在多个大脑区域广泛分布的神经活动组织这些强大的记忆引导行为仍然不清楚.
研究的目的:
- 调查分散的神经元活动的集体组织,
- 探索可卡因相关记忆在灭绝后的神经机制.
主要方法:
- 同时监测小鼠前额叶皮层,内核,杏仁体,海马体和腹膜区域 (VTA) 的神经活动.
- 在可卡因相关记忆的回忆,灭绝和更新阶段的神经振荡的分析.
- 研究VTA输出路径和特定频段 (beta和theta) 在记忆表达中的作用.
主要成果:
- 在记忆检索过程中,在多个大脑网络中发现了短暂协调,短暂的β频活动的高阶模式.
- 由4Hz振荡驱动的VTA质神经元的分离途径被发现驱动了这种多网络β频段协同激活.
- 这种神经活动的封闭循环抑制阻止了可卡因偏见的复发.
结论:
- 大脑分布的神经活动的时间结构协调,特别是通过多网络β频振荡,可能是强大的记忆表达的关键组织原则.
- 这种由VTA途径驱动的协调活动对于获取和更新与药物相关的记忆至关重要.
- 针对这些特定的神经动态提供了一种潜在的策略来防止不适应性行为的复发.
相关概念视频
Working Memory
171
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
171
Role of Cerebellum and Prefrontal Cortex in Memory
436
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
436
Higher Mental Functions of Brain: Learning and Memory
809
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
809
Interference and Decay
142
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
142
Role of Neurotransmitters in Memory
562
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
562
Storage
86
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
86


