过敏性鼻炎表型与儿童不同的转录组概况:一个出生队列
Youn Ho Shin1, Jeong-Hyun Kim2, Si-Hyeon Lee2
1Department of Pediatrics, The Catholic University of Korea, Yeouido St Mary's Hospital, Seoul, Korea.
The Journal of allergy and clinical immunology
|January 19, 2024
概括
这项研究确定了五种儿童过敏性鼻炎 (AR) 表型,揭示了不同的临床轨迹和潜在的免疫机制. 早期发病的AR与食物/吸入剂敏感性和喘有关,而晚期发病的形式与吸入剂敏感性和支气管过敏反应有关.
科学领域:
- 儿科过敏和免疫学
- 遗传学和基因组学 遗传学和基因组学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 儿童过敏性鼻炎 (AR) 现型缺乏明确的定义.
- 了解这些表型对于有针对性的干预至关重要.
研究的目的:
- 在儿童中识别出不同的过敏性鼻炎 (AR) 现型.
- 研究每个AR表型的自然过程,临床特征和转录特征.
主要方法:
- 在一个由1050名从出生到12岁的儿童组成的出生队伍上利用了潜阶级轨迹分析.
- 进行了血液转录组分析,以阐明已识别的AR表型的分子机制.
主要成果:
- 确定了五种AR表型:早期发病 (8.4%),中间过渡性 (10.5%),晚期发病 (19.9%),非常晚发病 (17.8%),以及从未/不经常 (43.4%).
- 早期发病的AR与更高的严重程度,早期食物/吸入剂敏感性和喘症状 (没有BHR) 相关.
- 晚期和非常晚期的AR表型与吸入剂敏感化,喘和支气管过敏反应 (BHR) 相关,具有明显的时间敏感化模式.
结论:
- 早期发病的AR的特征是早期敏感和喘症状,与与BHR相关的晚期发病表型不同.
- 转录组数据揭示了早期和晚期AR的独特免疫反应途径,突出了不同的潜在机制.
更多相关视频
12:08Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
Published on: March 10, 2016
11.2K
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
30.3K
相关概念视频
Allergic Reactions
27.4K
Overview
27.4K
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management
405
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
405
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
