功能对抗性和对人类肠道微生物生物合成潜力的洞察力
Aehtesham Hussain1, Umera Patwekar1, Dattatray S Mongad1
1NCMR- National Centre for Cell Science (NCCS), Pune- 411007, India.
International journal of antimicrobial agents
|January 19, 2024
概括
人的肠道微生物产生专门的分子,抑制特定的细菌,提供对病原体的防御. 这一发现可能会导致新的抗微生物药物用于打击耐药性.
科学领域:
- 微生物学 微生物学
- 自然产品 化学 化学
- 基因组学就是基因组学.
背景情况:
- 共生微生物产生专门的小分子,影响宿主相互作用.
- 由微生物菌株及其分子调解的敌对相互作用对于肠道平衡至关重要.
- 了解这些相互作用是开发新型治疗策略的关键.
研究的目的:
- 为了阐明人类肠道共生微生物中的对抗性景观.
- 确定菌株特定的抗微生物相互作用及其潜在的分子机制.
- 探索肠道微生物作为新抗菌剂来源的潜力.
主要方法:
- 选330个人类肠道衍生的共生微生物菌株的对抗性活性.
- 代表性菌株的基因组测序,以确定生物合成基因集群 (BGCs).
- 对健康个体的菌株秘密和元基因组数据的分析.
主要成果:
- 确定了特定菌株的选择性抑制,与宽谱抗生素形成鲜明对比.
- 发现了重要的BGCs编码复合家族,负责对抗性活动.
- 在健康的肠道微生物组中发现了大量的这些BGC的子集,与宿主防御有关.
- 揭示了与关键途径相关的菌株分泌体中的潜在生物标志物.
结论:
- 人体肠道共生微生物具有生物合成的新奇性,并产生独特的天然产品.
- 这些天然产品对于宿主防御和维持肠道平衡至关重要.
- 这些已识别的化合物代表了开发新抗微生物药物的有希望来源,以对抗抗生素耐药性.
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