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现场凝:用于药物输送的智能载体

Akash Garg¹, Rutvi Agrawal¹, Chetan Singh Chauhan¹

¹Bhupal Noble's University, New Shiv Nagar, Central Area, Udaipur, Rajasthan 313001, India.

International journal of pharmaceutics

|January 19, 2024

概括

现场凝技术通过溶液到凝的过渡提供了可控的药物释放. 本综述涵盖了in-situ凝类型,机制和针对各种疾病的向药物输送中的应用.

科学领域:

制药科学制药科学
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

现场凝技术利用"sol to gel"过渡来持续释放药物.
这些凝是交叉链接的聚合物网络,通常是水凝,由温度,pH或离子等刺激触发.
虽然提供了诸如改善患者遵从性和局部交付等好处,但挑战包括药物降解和机械限制.

研究的目的:

审查in-situ凝的类型,形成机制和各种应用.
突出现场凝药物输送系统的优缺点.
通过多种给药途径探索in-situ凝在治疗各种疾病中的使用.

主要方法:

审查现有关于in-situ凝技术的文献.
基于响应性的in-situ凝的分类 (温度,pH,离子,多响应).
讨论控制in-situ凝形成的物理和化学机制.

主要成果:

在现场的凝表现出基于聚合物组成和刺激反应的调节性质.
多反应性凝显示出增强的药物释放概况.
在眼,鼻,口腔和阴道药物输送中证明了成功的应用.

结论:

现场凝技术是用于控制和向药物输送的多功能平台.
了解凝机制和刺激反应是优化治疗结果的关键.
对多响应系统和克服局限性的进一步研究将扩大其临床实用性.

关键词:

嘴唇的口腔是什么意思药物输送是药物输送的过程.在现场凝凝.机理机制机理机制眼球眼球眼球眼球眼球阴道阴道的阴道

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